ABSTRACT
Sanrentang， originally contained in the Regulations on Febrile Diseases written by WU Ju-tong in the Qing dynasty， was composed of eight traditional Chinese herbs to treat damp-warm diseases. It is a treatment method of gradually clearing away damp heat of tri-jiao， with characteristics of separating dispersion and mobilizing discharge. "Separating dispersion" means dispersion in separated ways， with different ways to eliminate dampness to export the dampness， heat， evil and turbid out of the body. "Mobilizing discharge" means discharge to stretch and unblock the Qi， to get rid of dampness and evil. It can be seen， Sanrentang， as a desiccating formula， taking "separating dispersion and mobilizing discharge" as the cubic basis， has a significant effect on both internal and external dampness associated with pathogenic heat syndrome， and its clinical application is quite extensive. After consulting the data of the past 10 years， the authors gave a brief overview on the syndrome theory， clinical application and pharmacological effects of Sanrentang， and elaborated the therapeutic effect and pharmacological effect of Sanrentang in the clinical application of upper， middle and lower Tri-jiao respectively， providing theoretical reference for effective development and utilization of Sanrentang. Coronavirus disease-2019（COVID-19） swept the world in early 2020 and it is a great challenge for the medical community to seek for effective prevention and treatment methods. For COVID-19， although the cause of the disease belongs to the Qi of "pestilence"， many doctors have different opinions on the pathogenic characteristics. However， they all agree with the clinical characteristics of "dampness". COVID-19， which has the attribute of "dampness evil"， is so sticky that it can't be cured at once. In addition to the main symptoms such as fever and cough， it is also characterized by the middle-jiao dampness symptoms such as poor appetite， fullness of abdomen， loose stool and diarrhea. It is worthy to further explore the application prospect of Sanrentang in COVID-19 prevention and treatment.
ABSTRACT
<p><b>OBJECTIVE</b>To identify factors closely associated with plasma B type natriuretic peptide (BNP) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) levels.</p><p><b>METHODS</b>A total of 1983 people (mean 66 years-old and 694 male) underwent annual health check-up in 2006 in Okuizumo district were included in this study. Blood pressure, electrocardiogram, conventional blood examination, plasma BNP and NT-proBNP were measured.</p><p><b>RESULTS</b>BNP is positively correlated with NT-proBNP (r = 0.89, P < 0.01). Multiple regression analysis showed that age, Hb, pulse rate, SBP, TC, gender, TG and creatinine were significantly related to BNP and age, creatinine, Hb, gender, TG, TC, SBP, pulse rate were significantly related to NT-proBNP. NT-proBNP was more easily affected by renal function changes and BNP was more easily affected by autonomic nervous system changes. Both BNP and NT-proBNP significantly increased in proportion to SBP and age. NT-proBNP and BNP were significantly higher in females compared with males (all P < 0.05). NT-proBNP and BNP were also negatively correlated with abdominal circumference (all P < 0.05).</p><p><b>CONCLUSION</b>In this study population, NT-proBNP and BNP were closely associated with age, blood pressure, creatinine, pulse rate, lipid levels, gender and abdominal circumferences.</p>